HRID1074366

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1118

Sulfuric acid

H2O4S

结构：Nc1nc(C(=NOC2CC2)C(=O)N[C@@H]2C(=O)N3C(C(=O)[O-])=C(C[n+]4ccccc4)CS[C@H]23)cs1

HCID131716059

未命名化合物

PRODUCTS

生成物

结构：Nc1nc(C(=NOC2CC2)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(C[n+]4ccccc4)CS[C@H]23)cs1.O=S(=O)([O-])O

HCID131716081

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

To a solution of 7β-[2-(2-aminothiazol-4-yl)-2-(cyclopropyloxyimino)acetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylate (syn isomer) (750 mg) in water (50 ml) was added concentrated sulfuric acid (0.0679 ml). The solution was lyophilized to give 7β-[2-(2-aminothiazol-4-yl)-2-(cyclopropyloxyimino)acetamido]-3-(1-pyridinio)methyl-3-cephem-4-carboxylic acid hydrogen sulfate (863 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cd323590918f4eb491a6d8ccbe4f7013
来源数据集: uspto-grants-1990_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04973699
来源说明: uspto-grants-1990_11

反应 SMILES

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:30][O:31][CH:32]2[CH2:34][CH2:33]2)[C:8]([NH:10][C@@H:11]2[C:28](=[O:29])[N:13]3[C:14]([C:25]([O-:27])=[O:26])=[C:15]([CH2:18][N+:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1.[S:35](=[O:39])(=[O:38])([OH:37])[OH:36]>O>[S:35]([O-:39])([OH:38])(=[O:37])=[O:36].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:30][O:31][CH:32]2[CH2:34][CH2:33]2)[C:8]([NH:10][C@@H:11]2[C:28](=[O:29])[N:13]3[C:14]([C:25]([OH:27])=[O:26])=[C:15]([CH2:18][N+:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1