Morpholine → 6-(4-Morpholinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

HRID 1074394Notes

Reaction equation

HRID 1074394 reaction equation
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][CH:13]=[CH:14][N:4]2[N:3]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][CH:13]=[CH:14][N:4]3[N:3]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 131789756-Chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

Product 1

HCID 131789806-(4-Morpholinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

Procedure

A mixture of 10 g of 6-chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine and 20.9 g of morpholine was heated at reflux for 72 hours. The mixture was then poured into about 200 ml of ice water and a solid formed immediately. This was separated by filtration and air-dried to give 6-(4-morpholinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine melting at about 160°-161° C. This compound has the following structural formula ##STR3##

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 72 hours
  3. customa solid formed immediately
  4. customThis was separated by filtration
  5. customair-dried

Sources & evidence

ORD record
ord-a30ba0add6a54180bea0029e7774175f
Source dataset
uspto-grants-1983_07
Patent number
US04391807

Reaction notes

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