Hydrochloric Acid → HCID 14391171, compound

Participants

Reaction Steps

Aqueous NaOH solution (1 N, 15.5 ml) was added to a solution of 6-methoxy-5-(trifluoromethylthio)-1-naphthalenecarboxylic acid methyl ester (2.45 g, 7.7 mmoles) in 2-methoxyethanol (60 ml). The resulting solution was stirred at room temperature for 24 hr, cooled in an ice-bath, made acidic (pH=3) by the addition of 1 N aqueous HCl and diluted with water. The resulting solid was collected, washed with water and recrystallized from ethanol to give the title compound (1.7 g); mp 204°-205° C.; NMR (DMSO-d6) δ 4.00 (s, 3H), 8.20 (m, 5H), 10.30 (broad, 1H).

Provenance & Evidence