Epichlorohydrin → 1,2-epoxy-3-(2-methyl-3,4-dihydro-2H-1-benzopyrane-7-yloxy)-propane

HRID 1074462Notes

Reaction equation

[OH:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][CH:8]([CH3:10])[O:9][C:4]=2[CH:3]=1.Cl[CH2:14][CH:15]1[O:17][CH2:16]1>>[O:17]1[CH:15]([CH2:14][O:1][C:2]2[CH:12]=[CH:11][C:5]3[CH2:6][CH2:7][CH:8]([CH3:10])[O:9][C:4]=3[CH:3]=2)[CH2:16]1

Participants

Reactant 2

HCID 7835Epichlorohydrin

HCID 12197347HCID 12197347, compound

Product 1

HCID 204967211,2-epoxy-3-(2-methyl-3,4-dihydro-2H-1-benzopyrane-7-yloxy)-propane

Procedure

Starting from 7-hydroxy-2-methyl-3,4-dihydro-2H-1-benzopyrane, using 1-chloro-2,3-epoxypropane reagent and following the process of example 9 (b), 1,2-epoxy-3-(2-methyl-3,4-dihydro-2H-1-benzopyrane-7-yloxy)-propane was obtained (m.p. 67°-69° C.).

Sources & evidence

ORD record: ord-99f3f622159240feb4582b168f0ab284
Source dataset: uspto-grants-1983_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04391821

Reaction notes

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