Tert-Butylamine → HCID 20496732, compound

Participants

Reaction Steps

A solution of 10.0 g 7-(2-hydroxy-3-chloro-1-propyloxy)-4H-1-benzopyrane-4-one with 100 cm3 ethanol was boiled with 20 cm3 1,1-dimethylethylamine for 2.5 hours. The solution was evaporated under reduced pressure, the residue was dissolved in 200 ml ethanol, to the obtained solution 40 ml 10% aqueous hydrochloric acid was added and the mixture was boiled for 10 minutes. The solvent was removed under reduced pressure and the residue was crystallized from aceton; 1-(4H-1-benzopyrane-4-one-7-yloxy)-3-(1,1-dimethylethylamino)-2-propanol hydrochloride salt (m.p. 176°-178° C.) was obtained.

Provenance & Evidence