HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Diphenylacetone → 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Diphenylacetone | HCID 69907 | — |
| Reactant | 3-Bromo-1,1-diphenylacetone | HCID 2794635 | — |
| Reactant | 5,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol | HCID 3866487 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide | HCID 15571212 | — |
Reaction Steps
A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone as described in Example 22. This 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 1.0 g. of tetrahydro-5,5-dimethyl-2(1H)-pyrimidinethione in 50 ml. of acetone. The mixture is allowed to stand at room temperature for 24 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 259°-261° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04393004 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-3130c19ef8eb4df6a7981fdcec590ce9 |
| Source note | uspto-grants-1983_07 |