3-Bromo-1,1-diphenylacetone → HCID 20495741, compound

HRID 1074536Notes

Reaction equation

HRID 1074536 reaction equation
[Br:1][CH2:2][C:3](=[O:17])[CH:4]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[NH:18]1[CH2:24][CH:23]=[CH:22][CH2:21][NH:20][C:19]1=[S:25]>CC(C)=O>[BrH:1].[C:5]1([CH:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]2([OH:17])[N:20]3[CH2:21][CH:22]=[CH:23][CH2:24][N:18]=[C:19]3[S:25][CH2:2]2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 27946353-Bromo-1,1-diphenylacetoneHCID 20495740HCID 20495740, compound

Product 1

HCID 20495741HCID 20495741, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

This 1-bromo-3,3-diphenyl-2-propanone is dissolved in 50 ml. of acetone and added to a warm solution of 1.28 g. of 1,3,4,7-tetrahydro-2H-1,3-diazepin-2-thione in 100 ml. of acetone. The reaction mixture is warmed, with stirring, for 3 hours and then stirred for 72 hours. The mixture is cooled and the resulting solid is collected by filtration, giving the desired product.

Workup

  1. temperatureThe reaction mixture is warmed
  2. stirringstirred for 72 hours
  3. temperatureThe mixture is cooled
  4. filtrationthe resulting solid is collected by filtration

Sources & evidence

ORD record
ord-912520ef13534510bc6ad7812aa202de
Source dataset
uspto-grants-1983_07
Patent number
US04393004

Reaction notes

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