Dichloromethane → HCID 73680114, compound

Participants

Reaction Steps

To a solution of 2-triphenylphosphoranylideneacetaldehyde (1.9 g) in methylene chloride (15 ml) was added dropwise little by little a solution of isopropyl ester of 4-(2-chlorophenyl)-6-formyl-5-methoxycarbonyl-2-methyl-1,4-dihydropyridine-3-carboxylic acid (2.14 g) in methylene chloride (25 ml) with stirring over a period of 50 minutes, and the stirring was continued at ambient temperature for an hour. After removal of the methylene chloride from the reaction mixture, the residue was dissolved in benzene (10 ml) and subjected to column chromatography over silica gel (120 g). Elution was carried out with a mixture of benzene and ethyl acetate (10:1 by volume), and fractions containing a desired compound were collected and evaporated to dryness under reduced pressure to give orange needles of isopropyl ester of 4-(2-chlorophenyl)-6-(2-formylvinyl)-5-methoxycarbonyl-2-methyl-1,4-dihydropyridine-3-carboxylic acid (1.0 g), mp 179°-180.5° C.

Provenance & Evidence