Potassium Carbonate → HCID 12812973, compound

Participants

Reaction Conditions

Reaction Steps

25 g of 7-chloro-4-ethoxycarbonyl-1(2H)-isoquinolone was dissolved in 100 ml of dimethylformamide while warming, and 27 g of anhydrous potassium carbonate was added to the solution, followed by stirring for 2 hours at 110° C. Then, 14 g of 3-chloropropanol was added thereto and the stirring was continued for 5 hours at 110° C.The solvent was distilled off and the residue was dissolved in dichloromethane. The solution was washed with water, dried and the solvent was distilled off. The resulting crystals were recrystallized from a mixture of ethanol and petroleum ether to obtain 20.1 g of 7-chloro-4-ethoxycarbonyl-2-(3-hydroxypropyl)-1-(2H)-isoquinolone having a melting point of 193° C. as colorless prisms.

Provenance & Evidence