Potassium Hydroxide → HCID 12812974, compound

Participants

Reaction Steps

Then, 20.1 g of 7-chloro-4-ethoxycarbonyl-2-(3-hydroxypropyl)-1(2H)-isoquinolone was dissolved in 50 ml of ethanol, and 100 ml of an ethanolic solution of 5.5 g of potassium hydroxide was added to the resulting solution, followed by thoroughly stirring. The resulting solution was then poured into ice-water and the mixture was filtered. The filtrate was rendered neutral with dilute acetic acid and the precipitated crystals were filtered and washed with water. Recrystallization from a mixture of ethanol and petroleum ether gave 16.4 g of 4-carboxy-7-chloro-2-(3-hydroxypropyl)-1(2H)-isoquinolone having a melting point of 193° C. as colorless prisms.

Provenance & Evidence