Carbon Tetrachloride → HCID 12812977, compound

Participants

Reaction Steps

Then, 12.5 g of 4-carboxy-2-(3-hydroxypropyl)-1(2H)-isoquinolone was added to a mixture of 50 ml of carbon tetrachloride and 25 ml of thionyl chloride, and the resulting mixture was heated at reflux for 2 hours. The solvent was distilled off and the residue was dissolved in dichloromethane. The solution was washed with water, dried and the solvent was distilled off. The resulting crystals were recrystallized from a mixture of ethyl acetate and petroleum ether to obtain 12.8 g of 4-chlorocarbonyl-2-(3-chloropropyl)-1(2H)-isoquinolone having a melting point of 101° C. as colorless prisms.

Provenance & Evidence