Diphenyl Ether → HCID 12812981, compound

Participants

Reaction Steps

Then, 13.7 g of ethyl p-chlorophenyl-(α-ethoxycarbonylaminomethylene)acetate was added to 50 ml of diphenyl ether and the mixture was heated at reflux for 3 hours. After cooling, benzene and petroleum ether were added to the reaction mixture, and the precipitated crystals were filtered and recrystallized from a mixture of dimethylformamide and ethanol to obtain 7 g of 7-chloro-4-ethoxycarbonyl-1(2H)-isoquinolone having a melting point of 243° C. as colorless prisms.

Provenance & Evidence