3-Hydroxybenzoic Acid → 3-[2-Chloro-4-(trifluoromethyl)phenoxy]benzoic acid

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Reaction Steps

3-Hydroxybenzoic acid is an important intermediate product for the preparation of plant protection agents. Thus, in accordance with U.S. Pat. No. 4,031,131, 3-hydroxybenzoic acid can be reacted with 3,4-dichlorobenzotrifluoride in methanolic solution and in the presence of potassium hydroxide and dimethyl sulphoxide, to give 3-(2-chloro-4-trifluoromethylphenoxy)-benzoic acid. Nitrating this benzoic acid with potassium nitrate in concentrated sulphuric acid then gives 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrobenzoic acid which, according to U.S. Pat. No. 3,798,276, is an important herbicide.

Provenance & Evidence