HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Pyridine, 2-[[1-(2,5-dimethylphenyl)ethyl]sulfonyl]-3-methyl-, 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Pyridine, 2-[[(2,5-dimethylphenyl)methyl]sulfinyl]-3-methyl-, 1-oxide | HCID 501194 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Pyridine, 2-[[1-(2,5-dimethylphenyl)ethyl]sulfonyl]-3-methyl-, 1-oxide | HCID 501193 | — |
Reaction Steps
To a stirred suspension of 3 g (0.01 mol) of sulfone (described in Example 3) in 15 mL of dry dimethylformamide cooled in an ice bath, is added 0.5 g sodium hydroxide powder. To this mixture is slowly added 0.75 mL methyl iodide. The reaction mixture is warmed to room temperature and stirred for 2 hours. 100 mL ice-water is slowly added with stirring. After filtration the white solid is recrystallized from toluene. Melting point: 146°-147° C. Structure confirmed by NMR. I.R. N→O 1250 cm-1, SO2 1350, 1140 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04394155 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-3f446f9dcafd45a79de8a5091ae75ef7 |
| Source note | uspto-grants-1983_07 |