反应详情

To diethyl-bis-(hydroxymethyl)malonate (50 g) in acetone (50 ml) and benzene (200 ml) is added phosphoric acid (10 g). . The mixture is refluxed while stirring and separating water which distills. When water evolution is complete, the reaction mixture is cooled and the organic layer is separated, stirred with solid sodium carbonate (10 g), filtered and evaporated to give the title product (52 g) (87%) nD26 1.4412.

1. temperatureThe mixture is refluxed
2. customseparating water which
3. distillationdistills
4. temperaturethe reaction mixture is cooled
5. customthe organic layer is separated
6. stirringstirred with solid sodium carbonate (10 g)
7. filtrationfiltered
8. customevaporated