1H-1,2,4-Triazole → HCID 20495227, compound

HRID 1074888Notes

Reaction equation

HRID 1074888 reaction equation
Cl[CH:2]([O:4][CH2:5][CH:6]=[CH2:7])[CH3:3].[NH:8]1[CH:12]=[N:11][CH:10]=[N:9]1>C(#N)C>[N:8]1([CH:2]([O:4][CH2:5][CH:6]=[CH2:7])[CH3:3])[CH:12]=[N:11][CH:10]=[N:9]1

Participants

4

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 13099177HCID 13099177, compound

Product 1

HCID 20495227HCID 20495227, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Allyl 1-chloroethyl ether (3.6 g; Black and Lander, J.C.S., 1965, 5525) and 1,2,4-triazole (6.9 g) in acetonitrile (75 ml) were refluxed for 6 hours. The solvent was removed under reduced pressure; the residual solid was heated with water and extracted with diethyl ether. The ethereal phase was washed with water and dried over magnesium sulphate, and the solvent was removed. The residual oil was purified by passing through a column of silica gel, eluting with ethyl acetate to give the title compound as a colourless oil.

Workup

  1. customThe solvent was removed under reduced pressure
  2. temperaturethe residual solid was heated with water
  3. extractionextracted with diethyl ether
  4. washThe ethereal phase was washed with water
  5. dry with materialdried over magnesium sulphate
  6. customthe solvent was removed
  7. customThe residual oil was purified
  8. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-462a6f848cf64d85bb63d2d8015beb3e
Source dataset
uspto-grants-1983_07
Patent number
US04394380

Reaction notes

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