反应详情

A suspension of α-1,2,4-triazol-1-yl-p-chloroacetophenone (4 g) in methanol (12 ml) was treated with sodium borohydride (0.5 g) with cooling and stirring. The mixture was then left at room temperature for 0.5 hour and refluxed for 1 hour. The methanol was removed under reduced pressure and water (25 ml) was added followed by dilute hydrochloric acid (10 ml). The white solid was filtered, washed with water and dried. Crystallisation from ethyl acetate-petroleum ether (60°-80°) gave the title compound as a white crystalline solid. Analysis:

1. temperaturewith cooling
2. temperaturerefluxed for 1 hour
3. customThe methanol was removed under reduced pressure and water (25 ml)
4. additionwas added
5. filtrationThe white solid was filtered
6. washwashed with water
7. customdried
8. customCrystallisation from ethyl acetate-petroleum ether (60°-80°)