反应详情

A solution of α-isopropyl-4-difluoromethoxyphenylacetyl chloride (4.58 mmol) in ether (5 ml) is added to an ether (20 ml) solution of α-cyano-m-phenoxybenzyl alcohol (4.58 mmol) and pyridine (0.5 ml). The mixture is stirred overnight and filtered. The filtrate and the washings are evaporated and the residual oil is purified on 5×20 cm silica gel plates using 1:1 methylenechloride-hexane as eluent. The band in the silica gel plate is extracted with ether and evaporated to give the desired ester as an oil.

1. filtrationfiltered
2. customThe filtrate and the washings are evaporated
3. customthe residual oil is purified on 5×20 cm silica gel plates
4. extractionThe band in the silica gel plate is extracted with ether
5. customevaporated