Trifluoroacetic anhydride → HCID 13178614, compound

Participants

Reaction Steps

Trifluoroacetic anhydride, 71 ml (0.5 mol), was added dropwise to a 37.22 g (0.4 mol) sample of powdered 2-fluoroacetohydroxamic acid. The reaction mixture became liquid and warmed spontaneously to 60°. After cooling, the reaction mixture was evaporated to dryness under reduced pressure to give 70.3 g (93%) of N-(fluoroacetyl)-O-(trifluoroacetyl)hydroxylamine as a colorless, crystalline residue: mp 56°-59°; 1H NMR (CDCl3) δ 5.05 ppm (d, J=47 Hz, 2H) and 9.8 ppm (NH); 19F NMR (CDCl3) δ -233.8 ppm (t, J=47 Hz, 1F) and 73.8 ppm (s, 3F).

Provenance & Evidence