Hydrochloric Acid → HCID 20456493, compound

Participants

Reaction Steps

2-(2-Pyridylacetyl)-p-anisanilide (II) (25.0 g, 0.0722 mole) was dissolved with gentle warming in 500 ml THF. The bright yellow solution was chilled in an ice bath, and 6.5 ml (0.078 mole) 12 N HCl was added. The yellow color disappeared and a white precipitate formed immediately. The solid was collected on a filter; rinsed with THF and air-dried to give 27.4 g white solid (99.3%), m.p. 190.5°-191.5° (dec.).

Provenance & Evidence