Isopropyl iodide → HCID 15914138, compound

HRID 1074919Notes

Reaction equation

HRID 1074919 reaction equation
[SH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[CH:8](I)([CH3:10])[CH3:9]>C(O)C>[CH:8]([S:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1)([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 6362Isopropyl iodideHCID 178418431pyridine-4-thiol

Product 1

HCID 15914138HCID 15914138, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-mercaptopyridine (555 mg, 5 mmoles) and isopropyl iodide (0.50 ml) in ethanol (5 ml) was heated under reflux for 4 hours and then evaporated under reduced pressure. The residue was dissolved in a small amount of water, made alkaline with aqueous sodium hydroxide and extracted with ethyl acetate. The extract was washed with a small amount of water, dried and evaporated under reduced pressure to give the product as an oil. Yield, 670 mg (88%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. customevaporated under reduced pressure
  4. dissolutionThe residue was dissolved in a small amount of water
  5. extractionextracted with ethyl acetate
  6. washThe extract was washed with a small amount of water
  7. customdried
  8. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-2d227324c435477a802468069e8647ec
Source dataset
uspto-grants-1983_07
Patent number
US04394503

Reaction notes

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