反应详情

30 grams of ethyl nicotinate and 80 grams of 2-benzylthio ethylamine are heated for 12 hours at 170°-180° C. The ethane liberated during the reaction is removed by means of a Dean Stark apparatus. After cooling, the reaction mixture is dissolved in 400 cc of carbon tetrachloride; by addition of petroleum ether, the N-(2-benzylthioethyl)nicotinamide crystallizes: 47 g. By crystallization in a mixture of carbon tetrachloride and cyclohexane, there are recovered colorless crystals of the above product melting at 79° C.

1. customis removed by means of a Dean Stark apparatus
2. temperatureAfter cooling
3. dissolutionthe reaction mixture is dissolved in 400 cc of carbon tetrachloride
4. additionby addition of petroleum ether
5. customthe N-(2-benzylthioethyl)nicotinamide crystallizes
6. customBy crystallization
7. additionin a mixture of carbon tetrachloride and cyclohexane, there
8. customare recovered colorless crystals of the above product melting at 79° C.