Cysteamine Hydrochloride → HCID 53779263, compound

HRID 1074951Notes

Reaction equation

HRID 1074951 reaction equation
Cl.[SH:2][CH2:3][CH2:4][NH2:5].[O-:6][C:7]#[N:8].[K+].Cl[CH2:11][C:12]([O-:14])=[O:13].[Na+]>O>[NH:5]([CH2:4][CH2:3][S:2][CH2:11][C:12]([OH:14])=[O:13])[C:7]([NH2:8])=[O:6]

Participants

5

Reactant 3

HCID 9082Cysteamine HydrochlorideHCID 11378442Potassium cyanateHCID 23665759Sodium chloroacetate

Product 1

HCID 53779263HCID 53779263, compoundYield 78.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Conditions

Temperature
50 °C

Procedure

To a solution of 34.1 g of β-mercaptoethylamine hydrochloride in 200 cc of water there are added a solution of 24.3 g of potassium cyanate in 80 cc of water, then 36 g of sodium monochloroacetate in 200 cc of water. The solution is heated at 50° C. for 2 hours while maintaining the pH at 6 by the addition of 2 N soda. The mixture is then acidified, concentrated to dryness and washed with a mixture of water and ethanol. After filtration, there are produced 42 g of the product which melts at 135° C.

Workup

  1. temperaturewhile maintaining the pH at 6
  2. additionby the addition of 2 N soda
  3. concentrationconcentrated to dryness
  4. washwashed with a mixture of water and ethanol
  5. filtrationAfter filtration, there

Sources & evidence

ORD record
ord-7a9805ae5a3d4054bd142f82ad103335
Source dataset
uspto-grants-1983_07
Patent number
US04394520

Reaction notes

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