HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperidinecarboxamide → N-benzylpiperidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperidinecarboxamide | HCID 3772 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-benzylpiperidine-4-carboxamide | HCID 3868064 | 35% |
Reaction Steps
4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05723490 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-aad08f27e18e4070affc2570d3f9689b |
| Source note | uspto-grants-1998_03 |