反应详情

320 Mg. 8-chloro-3-cyanodibenzo[b,f]thiepin-5,5-dioxide is refluxed for 24 hours in a mixture of 10 cc. acetic acid and 10 cc. 50% aqueous sulfuric acid. The mixture is cooled down and the crystalline product filtered, washed with water and dried at 70° C., 0.5 mm./Hg., to yield 289 mg. (82%) of pure acid, m.p. 276°-278° C.

1. temperatureThe mixture is cooled down
2. filtrationthe crystalline product filtered
3. washwashed with water
4. customdried at 70° C.
5. custom, to yield 289 mg