Acetic Acid → HCID 20270263, compound

HRID 1075013Notes

Reaction equation

HRID 1075013 reaction equation
C([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[S:14][C:13]3[CH:15]=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=[CH:18][C:12]=3[CH2:11][CH2:10][C:9]=2[CH:22]=1)(=O)C.C(O)(=O)C.S(=O)(=O)(O)O>O>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]2[S:14][C:13]3[CH:15]=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=[CH:18][C:12]=3[CH2:11][CH2:10][C:9]=2[CH:22]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 20270221HCID 20270221, compound

Product 1

HCID 20270263HCID 20270263, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Reflux 200 mg. of 8-acetamido-10,11-dihydrodibenzo[b,f]thiepin-3-carboxylic acid for 16 hours in a mixture of 5 cc. of acetic acid and 5 cc. of 50% aqueous sulfuric acid. Dilute with water and separate the solids by filtration. Wash with water and dry to obtain the title product.

Workup

  1. temperatureReflux 200 mg
  2. customseparate the solids
  3. filtrationby filtration
  4. washWash with water
  5. customdry

Sources & evidence

ORD record
ord-5d560624c9324df1b7045cef4fcd07ff
Source dataset
uspto-grants-1983_07
Patent number
US04394515

Reaction notes

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