HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane → 3-Hydroxymethyl-10,11-dihydro-11-oxodibenzo[b,f]-thiepin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane | HCID 6331 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 5-oxo-6H-benzo[b][1]benzothiepine-2-carboxylic acid | HCID 827051 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Hydroxymethyl-10,11-dihydro-11-oxodibenzo[b,f]-thiepin | HCID 20270242 | — |
Reaction Steps
Dissolve 5.1 gm. of 10,11-dihydro-11-oxodibenzo[b,f]thiepin-3-carboxylic acid in 100 cc. of tetrahydrofuran and add 35 cc. of 1M borane in tetrahydrofuran at room temperature under a nitrogen atmosphere. Stir the mixture at room temperature for 3 hours. Slowly dilute the reaction mixture with water and then with ethyl acetate. Wash with aqueous sodium chloride, dry and evaporate to an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04394515 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-bb68a86f61774eafb9c9a82a3f8f387b |
| Source note | uspto-grants-1983_07 |