HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxypropionic acid → beta-Carboxyethyl 10,11-Dihydro-11-oxodibenzo[b,f]thiepin-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxypropionic acid | HCID 68152 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-Chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin | HCID 20270211 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | beta-Carboxyethyl 10,11-Dihydro-11-oxodibenzo[b,f]thiepin-3-carboxylate | HCID 20270225 | — |
Reaction Steps
Dissolve 1.0 gm. of 3-chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin in 20 cc. of tetrahydrofuran and add 1.0 gm. of the sodium salt of β-hydroxypropionic acid. Stir the mixture at room temperature for 18 hours. Filter and evaporate the filtrate to dryness. Recrystallize the solid residue from ethanol to obtain the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04394515 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-4b01b72f90834de680b1a5b2d55ce4bc |
| Source note | uspto-grants-1983_07 |