Ammonia → 3-N-[2-[[6-[(dimethylamino)methyl]-2-pyridinyl]methylsulfanyl]ethyl]-1,1-dioxo-1,2,5-thiadiazole-3,4-diamine

HRID 1075112Notes

Reaction equation

HRID 1075112 reaction equation
CO[C:3]1[C:7](OC)=[N:6][S:5](=[O:11])(=[O:10])[N:4]=1.[CH3:12][N:13]([CH2:15][C:16]1[N:21]=[C:20]([CH2:22][S:23][CH2:24][CH2:25][NH2:26])[CH:19]=[CH:18][CH:17]=1)[CH3:14].[NH3:27]>>[NH2:27][C:3]1[C:7]([NH:26][CH2:25][CH2:24][S:23][CH2:22][C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:15][N:13]([CH3:12])[CH3:14])[N:21]=2)=[N:6][S:5](=[O:11])(=[O:10])[N:4]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 212920152-[(6-Dimethylaminomethyl-2-pyridyl)methylthio]ethylamine

Product 1

HCID 1784832003-N-[2-[[6-[(dimethylamino)methyl]-2-pyridinyl]methylsulfanyl]ethyl]-1,1-dioxo-1,2,5-thiadiazole-3,4-diamine

Procedure

When a methanolic solution of 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide is successively treated with an equimolar amount of 2-[(6-dimethylaminomethyl-2-pyridyl)methylthio]ethylamine [prepared in Example 136, Step C] and excess ammonia, the title compound is thereby produced.

Sources & evidence

ORD record
ord-1153b399d01745d8bff0e4ac7ed9c128
Source dataset
uspto-grants-1983_07
Patent number
US04394508

Reaction notes

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