5-Chloro-2(1H)-pyrimidinone → HCID 22823685, compound

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Reaction Conditions

Reaction Steps

2-Desoxy-2-acetylamino-3,4,6-tri-O-actyl-D-glucopyranosylchloride (0.01 mol) and the potassium salt of 5-chloropyrimid-2-one (0.008 mol) were heated together in dimethylformamide (60 ml) with stirring at 80° C. for 24 hours. The solvent was then evaporated at reduced pressure (1 mm Hg) and the residue was extracted with chloroform (120 ml). The chloroform solution was washed with aqueous 1 N NaOH (2×3 ml) and water (3 ml) before drying (Mg SO4). Evaporation left the title compound which was further purified by trituration with ether and recrystallization from a small volume of methanol; yield 50%, m.p. 165°-167° C. when the sample is heated rapidly. (Found: C, 47.00; H, 4.82. Calc. for C18H22ClN3O9: : C, 47.02; H, 4.82)

Provenance & Evidence