Acetone → 5-Bromo-1-(prop-2-en-1-yl)pyrimidin-2(1H)-one

HRID 1075150Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH3:9][C:10]([CH3:12])=O>>[CH2:12]([N:4]1[CH:3]=[C:2]([Br:1])[CH:7]=[N:6][C:5]1=[O:8])[CH:10]=[CH2:9]

Participants

Reactant 2

HCID 180Acetone

HCID 1014945-Bromo-2(1H)-pyrimidinone

Product 1

HCID 156534875-Bromo-1-(prop-2-en-1-yl)pyrimidin-2(1H)-oneYield 40%

Procedure

1-Allyl-5-bromopyrimid-2-one was prepared from 5-bromopyrimid-2-one as above in 40% yield m.p. 142°-143° C. (acetone)

Sources & evidence

ORD record: ord-c706e29839ba40afac9e175a2040d43e
Source dataset: uspto-grants-1983_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04395406

Reaction notes

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