Chloroacetic Acid → HCID 20494276, compound

HRID 1075153Notes

Reaction equation

HRID 1075153 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.[OH-].[K+].Cl[CH2:12][C:13]([OH:15])=[O:14]>>[C:13]([CH2:12][N:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[N:6][C:5]1=[O:8])([OH:15])=[O:14]

Participants

4

Reactant 3

HCID 300Chloroacetic AcidHCID 14797Potassium HydroxideHCID 1085785-Chloro-2(1H)-pyrimidinone

Product 1

HCID 20494276HCID 20494276, compoundYield 47%

Procedure

A solution made from 5-chloropyrimid-2-one (0.015 mol), aqueous 0.78 M KOH (45 ml) and chloroacetic acid (0.018 mol) was heated under reflux until the pH had fallen to below 8. The solution was then concentrated to a small volume at reduced pressure. Addition of 1 N HCl (15 ml) caused the product to crystallize; yield 47%, m.p. 186°-188° C. (acetone). (Found: C, 38.35; H, 2.69. Calc. for C6H5ClN2O3 : C, 38.23; H, 2.67).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux until the pH
  3. concentrationThe solution was then concentrated to a small volume at reduced pressure
  4. additionAddition of 1 N HCl (15 ml)
  5. customto crystallize

Sources & evidence

ORD record
ord-ee285d3d0b5347439559aca28b0752a4
Source dataset
uspto-grants-1983_07
Patent number
US04395406

Reaction notes

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