5-Fluoropyrimidin-2-one → HCID 20494295, compound

HRID 1075154Notes

Reaction equation

[F:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.C[C:10]([CH3:12])=[O:11].C[OH:14]>>[C:10]([CH2:12][N:4]1[CH:3]=[C:2]([F:1])[CH:7]=[N:6][C:5]1=[O:8])([OH:14])=[O:11]

Participants

Reactant 2

HCID 1014985-Fluoropyrimidin-2-one

HCID 21894497Aceton-methanol

Product 1

HCID 20494295HCID 20494295, compoundYield 67%

Procedure

Prepared as above from 5-fluoropyrimid-2-one in 67% yield, m.p. 200°-202° (decomp) (acetone/methanol). (Found: C, 41.80; H, 3.10. Calc. for C6H5FN2O3 : C, 41.87; H, 2.93).

Sources & evidence

ORD record: ord-fa24d715132e4aa2a446482ca2d96514
Source dataset: uspto-grants-1983_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04395406

Reaction notes

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