Bromine → 2(1H)-Pyrimidinone, 5-bromo-1,4-dimethyl-

HRID 1075161Notes

Reaction equation

HRID 1075161 reaction equation
[Br:1]Br.[CH3:3][N:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[N:6][C:5]1=[O:11]>>[CH3:3][N:4]1[CH:9]=[C:8]([Br:1])[C:7]([CH3:10])=[N:6][C:5]1=[O:11]

Participants

3

Reactant 2

HCID 24408BromineHCID 20494286HCID 20494286, compound

Product 1

HCID 204942992(1H)-Pyrimidinone, 5-bromo-1,4-dimethyl-Yield 40%

Procedure

Bromine (0.012 mol) was added to an aqueous solution (100 ml) of 1,4-dimethylpyrimid-2-one (0.008 mole) and the reaction mixture left at room temperature for 3 hr before freeze-drying. The residual material was triturated with acetone and recrystallised from water; yield 40%, m.p. 170° C. (decomp.). (Found: C, 25.5; H, 2.9. Calc. for C6H7BrN2O HBr: C, 24.4; H, 2.8).

Workup

  1. custombefore freeze-drying
  2. customThe residual material was triturated with acetone
  3. customrecrystallised from water

Sources & evidence

ORD record
ord-482087692a934258a0baeb94c2865260
Source dataset
uspto-grants-1983_07
Patent number
US04395406

Reaction notes

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