HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → 5-Fluoro-4-thiouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-Fluoro-4-thiouracil | HCID 2781213 | 80% |
Reaction Steps
Prepared from 5-fluorouracil by the method of Ueda and Fox (see above) using phosphorus pentasulphide in pyridine. We find that dioxan is a better solvent in this reaction in which case the yield was 80% of a more pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04395406 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-2a6589d625fe475292c6216055f43040 |
| Source note | uspto-grants-1983_07 |