Methyl iodide → HCID 12534511, compound

Participants

Reaction Steps

Methyl iodide (0.017 mol) was added to the potassium salt of 4-methylthio-5-fluoropyrimid-2-one (0.012 mol) in dimethylformamide (50 ml) and the reaction mixture was stirred at room temperature for 24 h before evaporation at reduced pressure (1 mm Hg). The residue was extracted with chloroform and the solution was washed with aqueous 2 N NaOH, with water and was dried (MgSO4) before evaporation. The product was recrystallized from EtOAc/ligroin; yield 76%, m.p. 154° C. (Found: C, 41.48; H, 4.10. Calc. for C6H7FN2OS: C, 41.37; H, 4.05).

Provenance & Evidence