2-Bromoethanol → HCID 12534514, compound

Participants

Reaction Steps

Ethylene bromohydrin (0.023 mol) was added to a solution of the potassium salt of 4-methylthio-5-fluoropyrimid-2-one (0.015 mol) in dimethylformamide (65 ml) and the reaction mixture was stirred at room temperature for 24 h before evaporation at reduced pressure (1 mm Hg). The residue was extracted with chloroform, the solution was washed with aqueous 2 N NaOH, with water and was dried (MgSO4) before evaporation. The solid residue was recrystallized from acetone; yield 77%, m.p. 161°-162° C. (Found: C, 41.36; H, 4.62. Calc. for C7H9FN2O2S: C, 41.17; H, 4.44).

Provenance & Evidence