HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 5-Chloro-6-methyl-4-(methylsulfanyl)pyrimidin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 20494272 | HCID 20494272 | — |
| Product | 5-Chloro-6-methyl-4-(methylsulfanyl)pyrimidin-2(1H)-one | HCID 20491768 | 65% |
Reaction Steps
Methyl iodide (0.012 mol) was added to an aqueous solution prepared from 5-chloro-6-methyl-4-thiouracil (0.01 mol) and 0.725 M KOH (25 ml) and the reaction mixture was stirred at room temperature for 5 h. The solid precipitate formed was collected and was recrystallized from isopropanol; yield 65%, m.p. 268°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04395406 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-65bba7c767f14add9972328c1a728189 |
| Source note | uspto-grants-1983_07 |