N-methyl-2-pyrrolidone → HCID 13180323, compound

Participants

Reaction Steps

17.5 g of 2,4-dichlorobenzaldehyde, 22.4 g of 2-(4-chlorobenzyl)-4,4-dimethyl-2-oxazoline, 1 g of sodium bisulphate, 50 ml of 1-methyl-2-pyrrolidinone and 30 ml of xylene are heated at a bath temperature of 170° to 220° C., using a water separator, until 3.2 ml of water and 20 ml of xylene have been separated off. After cooling the reaction mixture, methanol is added and the title compound (m.>300° C.) is collected by filtration (yield: 24.8 g).

Provenance & Evidence