HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → 4-(4-Chlorophenyl)butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Product | 4-(4-Chlorophenyl)butyric acid | HCID 259740 | — |
| Product | Ethyl 4-(4-chlorophenyl)-4-oxobutanoate | HCID 10490261 | — |
Reaction Steps
4-(4-Chlorophenyl)-n-butyric acid was prepared by reacting 4-chlorobenzaldehyde with ethyl acetate and sodium cyanide to provide ethyl 4-(4-chlorophenyl)-4-oxo-butyrate, hydrolyzing the ethyl butyrate derivative to afford 4-(4-chlorophenyl)-4-oxobutyric acid, and then reducing the 4-oxo-group of said acid by reaction with zinc and hydrochloric acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04395410 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-811ee4256c0d4cef8181538753689bef |
| Source note | uspto-grants-1983_07 |