HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)phenyl isocyanate → 7-Chloro-2-(2-trifluoromethylphenylcarbamoyloxyamino)-5-phenyl-3H-1,4-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)phenyl isocyanate | HCID 16794 | — |
| Reactant | 7-chloro-2-hydroxyamino-5-phenyl-3H-1,4-benzodiazepine | HCID 12785862 | — |
| Solvent | N,N-dimethylformamide methanol | HCID 21901440 | — |
| Product | 7-Chloro-2-(2-trifluoromethylphenylcarbamoyloxyamino)-5-phenyl-3H-1,4-benzodiazepine | HCID 12785866 | — |
Reaction Steps
2 g of 7-chloro-2-hydroxyamino-5-phenyl-3H-1,4-benzodiazepine are reacted with 1 g of 2-trifluoromethylphenyl isocyanate, analogously to Experiment 1a. Yield: 1.8 g of colorless crystals of melting point 190° C. (from methanol/dimethylformamide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04395409 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-119c01d8cf994904ac4c64c7654cc1b9 |
| Source note | uspto-grants-1983_07 |