Phenyl isocyanate → HCID 12785880, compound

Participants

Reaction Steps

0.6 g of sodium bicarbonate and 0.5 g of hydroxylammonium chloride are added to 2 g of 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione in 40 ml of dioxane and 20 ml of dimethylformamide and the mixture is stirred for 8 hours at room temperature. Further addition of 0.2 g of sodium bicarbonate and 0.2 g of hydroxylammonium chloride, stirring for 1/2 hour at 50° C. and addition of 0.8 ml of phenylisocyanate yields, after the usual working up process, 0.7 g of colorless crystals of melting point 126° to 128° C. (from isopropanol).

Provenance & Evidence