Potassium Hydroxide → HCID 23690652, compound

HRID 1075267Notes

Reaction equation

HRID 1075267 reaction equation
C([NH:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10](=[O:16])[C:11]([O:13]CC)=[O:12])[N:5]=1)=O.[OH-].[K+:18]>C(O)C>[NH2:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10](=[O:16])[C:11]([O-:13])=[O:12])[N:5]=1.[K+:18]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 13752675HCID 13752675, compound

Product 1

HCID 23690652HCID 23690652, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A mixture of ethyl 2-(4-formamidopyrimidin-2-yl)glyoxylate and its monohydrate obtained in Preparation 6-(1) was dissolved in ethanol (30 ml.) and thereto was added dropwise 1 N ethanol solution of potassium hydroxide (11 ml.) under ice-cooling with stirring, and then stirring was continued for 2 hours at ambient temperature. The reaction mixture was filtered and the filtered precipitates were washed successively with a small amount of ethanol and diethyl ether and then dried to give a brown powder of potassium 2-(4-aminoprimidin-2-yl)glyoxylate (0.4 g.). The filtrate and washings were combined together and concentrated to the volume of about 15 ml, and to the residue was added diethyl ether (20 ml.). The precipitates were collected by filtration and washed successively with a small amount of ethanol and diethyl ether to give further a pale brown powder of a mixture of potassium 2-(4-aminopyrimidin-2-yl)glyoxylate and its monohydrate (0.8 g.).

Workup

  1. customobtained in Preparation
  2. temperaturecooling
  3. stirringstirring
  4. filtrationThe reaction mixture was filtered
  5. customthe filtered precipitates
  6. washwere washed successively with a small amount of ethanol and diethyl ether
  7. customdried

Sources & evidence

ORD record
ord-f60805b0dc2a4a7fb9035e33c1424bfe
Source dataset
uspto-grants-1983_07
Patent number
US04395411

Reaction notes

Loading…