HuagongsheHuagongshe Chemistry Print Report · For research reference only
NBD-Cl → (S)-1-[2-Methyl-3-[(4-nitrobenzofurazan-7-yl)thio]-1-oxopropyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | NBD-Cl | HCID 25043 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-(2-Methyl-3-sulfanylpropanoyl)-L-proline | HCID 12877547 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-1-[2-Methyl-3-[(4-nitrobenzofurazan-7-yl)thio]-1-oxopropyl]-L-proline | HCID 22823694 | — |
Reaction Steps
700 Mg of 1-(3-mercapto-2-methyl-1-oxopropyl)-L-proline, 700 mg of 4-chloro-7-nitrobenzofurazan (10% excess), 1 g sodium bicarbonate, and 10 ml dichloromethane were stirred at 20° C. for 16 hours. The reaction mixture was put in a 4×30 cm Silicar CC4 column, and eluted with C6H6 :CH3COOH (3:1) mixture (v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04395556 |
| Source dataset | uspto-grants-1983_07 |
| ORD ID | ord-5d648ce7d2f54ef0be26b6ca10d3f356 |
| Source note | uspto-grants-1983_07 |