反应详情

温度

25 °C

The crude 3-chloro-2-(1-ethoxyethoxy)-1-propyl acetate produced in Example 9 was added over a period of 1.5 hours to a stirred hot (105°) solution of 1.1 kg (27.5 moles) of sodium hydroxide in 1.1 L of water in a 5 L three-necked round-bottomed flask equipped with a mechanical stirrer, a reflux condenser, a dropping funnel, and a thermometer. The mixture was refluxed for an additional 4 hours period and then was allowed to cool to 25° C. The mixture was stirred with 1.5 L of water to dissolve inorganic salts and the phases were separated. The aqueous solution was extracted with 2 L of methylene chloride. Solvent was removed from the methylene chloride layer and the residual oil was combined with the above organic phase to give 1.2 kg of crude 3-(1-ethoxyethoxy) oxetane.

1. customequipped with a mechanical stirrer, a reflux condenser, a dropping funnel
2. temperatureThe mixture was refluxed for an additional 4 hours period
3. dissolutionto dissolve inorganic salts
4. customthe phases were separated
5. extractionThe aqueous solution was extracted with 2 L of methylene chloride
6. customSolvent was removed from the methylene chloride layer