Acetamide → N-(2-ethyl-5-nitrobenzyl)acetamide

Participants

Reaction Conditions

Reaction Steps

4-Ethylnitrobenzene (7.55 g; 0.05 mol) is added in small increments to a stirred solution of acetamide (5.9 g; 0.05 mol) and paraformaldehyde (1.6 g; 0.05 mol) in concentrated sulfuric acid (60 ml). This reaction mixture is stirred for 17 hours at 55° C. and then poured onto ice. A precipitate results which is recrystallized from butyl acetate to give 6.2 g (i.e., 56% yield) of product. This product has the following characteristics: melting point of 123° to 128° C.; i.r. 3275, 1640 and 1660 cm-1 (sh); mass. spec. m/e 222.

Provenance & Evidence