反应详情

N-hydroxymethyl benzamide (7.55 g; 0.05 mol) is added to a solution of p-nitrotoluene (0.85 g; 0.05 mol) in concentrated sulfuric acid (60 ml). The reaction mixture is stirred for 63 hours at room temperature and then poured onto ice. A colorless precipitate is obtained which is isolated and recrystallized repeatedly from aqueous ethanol to give 4.0 g (i.e., 30% yield) of product. Increasing the reaction time to 7 days gives a 43% yield of product compound. This product has the following characteristics: melting point of 134° to 137° C.; i.r. 3300, 1635, 1655 cm-1 (sh); mass. spec. m/e 270.

1. additionpoured onto ice
2. customA colorless precipitate is obtained which
3. customis isolated
4. customrecrystallized repeatedly from aqueous ethanol
5. customto give 4.0 g (i.e., 30% yield) of product
6. temperatureIncreasing the reaction time to 7 days