Ammonium Hydroxide → HCID 21791728, compound

Participants

Reaction Steps

1 g. of 6-[(4-Cyano-phenyl)-hydrazono]-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-one is heated in 10 g. of polyphosphoric acid at 180° C. for 30 minutes. After cooling the reaction mixture is diluted with 40 ml. of water and the pH is adjusted to 5 by adding 25 V/W% ammonium hydroxide solution. The precipitated product is filtered, washed with water and dried. 0.88 g. (92%) of 10-cyano-7,8-dihydro-5H,13H-indolo[2',3';3,4]-pyrido[2,1-b]quinazoline-5-one are obtained which after recrystallization from dimethylformamide melts at 255° C.

Provenance & Evidence