Acetic Anhydride → N-Acetyl 3-(5-pyrimidyl)aniline

HRID 1075450Notes

Reaction equation

[N:1]1[CH:6]=[C:5]([C:7]2[CH:8]=[C:9]([CH:11]=[CH:12][CH:13]=2)[NH2:10])[CH:4]=[N:3][CH:2]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[C:14]([NH:10][C:9]1[CH:11]=[CH:12][CH:13]=[C:7]([C:5]2[CH:6]=[N:1][CH:2]=[N:3][CH:4]=2)[CH:8]=1)(=[O:16])[CH3:15]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 71620493-Pyrimidin-5-ylaniline

Product 1

HCID 53813163N-Acetyl 3-(5-pyrimidyl)anilineYield 82%

Procedure

2b is acetylated with acetic anhydride to afford 2c (15.4g, 82%). Mp 157-158° C.

Sources & evidence

ORD record: ord-36ae0c097c9942fab2cd531b7b4c4292
Source dataset: uspto-grants-1999_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05902813

Reaction notes

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