HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 2-Dimethylaminopyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Dimethylaminopyrimidine | HCID 521717 | — |
Reaction Steps
A solution of 2-chloropyrimidine (5g, 43.65mmol) in dry THF (50ml) is saturated with gaseous dimethylamine. The mixture is stirred at ambient temperature for 1 hour followed by evaporation of solvent. The residue is partitioned between water and ethyl acetate. The aqueous phase is extracted with ethyl acetate. The combined organic phases are dried over sodium sulfate and evaporated to leave the product as a brownish oil. Yield 5.07g (94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05902813 |
| Source dataset | uspto-grants-1999_05 |
| ORD ID | ord-e8296edecc6243c580931539ada954ac |
| Source note | uspto-grants-1999_05 |